BRD-K49075727_nintedanib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K49075727_nintedanib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
CAST calpastatin
CDKN2A cyclin-dependent kinase inhibitor 2A
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
COBL cordon-bleu WH2 repeat protein
CYB5A cytochrome b5 type A (microsomal)
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPP4 dipeptidyl-peptidase 4
FGFR2 fibroblast growth factor receptor 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPER1 G protein-coupled estrogen receptor 1
GRAMD3 GRAM domain containing 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-B major histocompatibility complex, class I, B
HPSE heparanase
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LITAF lipopolysaccharide-induced TNF factor
MAOB monoamine oxidase B
MATN2 matrilin 2
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OPTN optineurin
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PENK proenkephalin
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PON2 paraoxonase 2
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL37A ribosomal protein L37a
RSAD2 radical S-adenosyl methionine domain containing 2
SC5D sterol-C5-desaturase
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFBR3 transforming growth factor, beta receptor III
TIMP1 TIMP metallopeptidase inhibitor 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ANXA5 annexin A5
AOX1 aldehyde oxidase 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL1A2 collagen, type I, alpha 2
CTTN cortactin
CYTH1 cytohesin 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
ELL2 elongation factor, RNA polymerase II, 2
EPHB2 EPH receptor B2
FAM46C family with sequence similarity 46, member C
FOLR1 folate receptor 1 (adult)
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IRS1 insulin receptor substrate 1
JAG1 jagged 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MMP2 matrix metallopeptidase 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
RHOH ras homolog family member H
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SRSF6 serine/arginine-rich splicing factor 6
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TCF4 transcription factor 4
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa