BRD-K49049886_CGS 15943_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K49049886_CGS 15943_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA1 actin, alpha 1, skeletal muscle
ADAM10 ADAM metallopeptidase domain 10
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL12 chemokine (C-X-C motif) ligand 12
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GNLY granulysin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMOX1 heme oxygenase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
JCHAIN joining chain of multimeric IgA and IgM
LPXN leupaxin
MAST4 microtubule associated serine/threonine kinase family member 4
MID1 midline 1
MME membrane metallo-endopeptidase
MX2 MX dynamin-like GTPase 2
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TBX3 T-box 3
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TMEM30B transmembrane protein 30B
TPPP3 tubulin polymerization-promoting protein family member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VEGFC vascular endothelial growth factor C
WIF1 WNT inhibitory factor 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
CKB creatine kinase, brain
CLDN3 claudin 3
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCR4 chemokine (C-X-C motif) receptor 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP1 insulin-like growth factor binding protein 1
ITGB1BP1 integrin beta 1 binding protein 1
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PRPF4 pre-mRNA processing factor 4
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPARCL1 SPARC-like 1 (hevin)
TUBB2A tubulin, beta 2A class IIa