BRD-K49010888_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K49010888_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANO1 anoctamin 1, calcium activated chloride channel
ANXA4 annexin A4
AREG amphiregulin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C10ORF10 chromosome 10 open reading frame 10
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CFI complement factor I
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL14A1 collagen, type XIV, alpha 1
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRA endothelin receptor type A
EFNA1 ephrin-A1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
FRZB frizzled-related protein
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAP43 growth associated protein 43
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM2 intercellular adhesion molecule 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2C integral membrane protein 2C
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LXN latexin
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYRF myelin regulatory factor
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFH neurofilament, heavy polypeptide
NLGN4X neuroligin 4, X-linked
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PENK proenkephalin
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIDT2 SID1 transmembrane family, member 2
SLC16A4 solute carrier family 16, member 4
SLC22A18 solute carrier family 22, member 18
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SRGN serglycin
SST somatostatin
STMN2 stathmin 2
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TMEM176A transmembrane protein 176A
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WASF1 WAS protein family, member 1
WIF1 WNT inhibitory factor 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABHD17A abhydrolase domain containing 17A
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM2 absent in melanoma 2
AK4 adenylate kinase 4
BLCAP bladder cancer associated protein
CA2 carbonic anhydrase II
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CDC25A cell division cycle 25A
COL4A5 collagen, type IV, alpha 5
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
CXCL13 chemokine (C-X-C motif) ligand 13
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GOLM1 golgi membrane protein 1
GRWD1 glutamate-rich WD repeat containing 1
HMG20B high mobility group 20B
IRS2 insulin receptor substrate 2
LMNB2 lamin B2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MFSD12 major facilitator superfamily domain containing 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOP16 NOP16 nucleolar protein
PODXL podocalyxin-like
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PURA purine-rich element binding protein A
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1B small proline-rich protein 1B
SRSF2 serine/arginine-rich splicing factor 2
TLR4 toll-like receptor 4
TMEM109 transmembrane protein 109
ZCCHC2 zinc finger, CCHC domain containing 2