BRD-K49010888_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

404 genes differentially expressed following the BRD-K49010888_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACKR3 atypical chemokine receptor 3
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CD99 CD99 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTSB cathepsin B
CTSL cathepsin L
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLRX glutaredoxin (thioltransferase)
GPR137B G protein-coupled receptor 137B
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
L1CAM L1 cell adhesion molecule
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LITAF lipopolysaccharide-induced TNF factor
LOXL2 lysyl oxidase-like 2
LPIN1 lipin 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MOSPD1 motile sperm domain containing 1
MSX1 msh homeobox 1
MT1X metallothionein 1X
MVP major vault protein
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
NTS neurotensin
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POR P450 (cytochrome) oxidoreductase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSAP prosaposin
PTN pleiotrophin
PTPRF protein tyrosine phosphatase, receptor type, F
PYGL phosphorylase, glycogen, liver
RAB29 RAB29, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL38 ribosomal protein L38
RRAS related RAS viral (r-ras) oncogene homolog
RTN2 reticulon 2
RTN3 reticulon 3
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STMN2 stathmin 2
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TIMP2 TIMP metallopeptidase inhibitor 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM2 transmembrane protein 2
TMEM41B transmembrane protein 41B
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VCAN versican
VCL vinculin
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANAPC15 anaphase promoting complex subunit 15
ANAPC5 anaphase promoting complex subunit 5
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BRD8 bromodomain containing 8
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
C1QBP complement component 1, q subcomponent binding protein
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DCXR dicarbonyl/L-xylulose reductase
DHFR dihydrofolate reductase
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EED embryonic ectoderm development
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EXO1 exonuclease 1
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FN3KRP fructosamine 3 kinase related protein
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGN2 high mobility group nucleosomal binding domain 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
ICAM3 intercellular adhesion molecule 3
ICT1 immature colon carcinoma transcript 1
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBNL1 muscleblind-like splicing regulator 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCERG1 transcription elongation regulator 1
TIMELESS timeless circadian clock
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TTK TTK protein kinase
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UMPS uridine monophosphate synthetase
VRK1 vaccinia related kinase 1
WDR12 WD repeat domain 12
ZWINT ZW10 interacting kinetochore protein