BRD-K48970916_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K48970916_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTG2 BTG family, member 2
C6ORF62 chromosome 6 open reading frame 62
CARS cysteinyl-tRNA synthetase
CD14 CD14 molecule
CD163 CD163 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSRP1 cysteine and glycine-rich protein 1
DAZAP2 DAZ associated protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELL2 elongation factor, RNA polymerase II, 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HP haptoglobin
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
KRT14 keratin 14, type I
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LPL lipoprotein lipase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MED1 mediator complex subunit 1
MMP9 matrix metallopeptidase 9
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NRIP1 nuclear receptor interacting protein 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PYCR1 pyrroline-5-carboxylate reductase 1
RBPMS RNA binding protein with multiple splicing
RSL1D1 ribosomal L1 domain containing 1
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SARS seryl-tRNA synthetase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
BST2 bone marrow stromal cell antigen 2
C1ORF106 chromosome 1 open reading frame 106
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHEK2 checkpoint kinase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTSV cathepsin V
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FRZB frizzled-related protein
GSTA1 glutathione S-transferase alpha 1
ICAM1 intercellular adhesion molecule 1
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGB5 integrin, beta 5
KRT7 keratin 7, type II
LAMP1 lysosomal-associated membrane protein 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
METRN meteorin, glial cell differentiation regulator
MSH6 mutS homolog 6
MSLN mesothelin
NT5DC2 5'-nucleotidase domain containing 2
PDIA3 protein disulfide isomerase family A, member 3
PHYH phytanoyl-CoA 2-hydroxylase
PLAC8 placenta-specific 8
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA2 replication protein A2, 32kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SDF4 stromal cell derived factor 4
SFRP1 secreted frizzled-related protein 1
SIDT2 SID1 transmembrane family, member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
TIMELESS timeless circadian clock
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TRIB2 tribbles pseudokinase 2