BRD-K48950795_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K48950795_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA6 annexin A6
ANXA9 annexin A9
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CD24 CD24 molecule
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLDN3 claudin 3
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DSTN destrin (actin depolymerizing factor)
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3 immediate early response 3
INSIG1 insulin induced gene 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LTA4H leukotriene A4 hydrolase
LXN latexin
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MDFIC MyoD family inhibitor domain containing
MMD monocyte to macrophage differentiation-associated
MMP10 matrix metallopeptidase 10
MSMO1 methylsterol monooxygenase 1
MUC1 mucin 1, cell surface associated
PBX1 pre-B-cell leukemia homeobox 1
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD21 RAD21 homolog (S. pombe)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPT10 septin 10
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TRIM2 tripartite motif containing 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WRB tryptophan rich basic protein

decreased expression

Symbol Name
BLCAP bladder cancer associated protein
CA2 carbonic anhydrase II
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
GRWD1 glutamate-rich WD repeat containing 1
HOMER1 homer scaffolding protein 1
IFI44L interferon-induced protein 44-like
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
MYBPC1 myosin binding protein C, slow type
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PPIF peptidylprolyl isomerase F
PTDSS1 phosphatidylserine synthase 1
RPL36 ribosomal protein L36
SEPT8 septin 8
TSPYL5 TSPY-like 5
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF593 zinc finger protein 593