BRD-K48803730_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K48803730_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
APOD apolipoprotein D
ASPH aspartate beta-hydroxylase
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FBXL12 F-box and leucine-rich repeat protein 12
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
GLRX glutaredoxin (thioltransferase)
GSTA1 glutathione S-transferase alpha 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
IRF9 interferon regulatory factor 9
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KRT23 keratin 23, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL2 lysyl oxidase-like 2
MAOB monoamine oxidase B
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NES nestin
NPTX2 neuronal pentraxin II
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PPAP2C phosphatidic acid phosphatase type 2C
PYGL phosphorylase, glycogen, liver
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAI2 snail family zinc finger 2
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TWF2 twinfilin actin binding protein 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
BCLAF1 BCL2-associated transcription factor 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
EMP1 epithelial membrane protein 1
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HOXC6 homeobox C6
ING3 inhibitor of growth family, member 3
KIF14 kinesin family member 14
LIG1 ligase I, DNA, ATP-dependent
LMO4 LIM domain only 4
LTF lactotransferrin
ODC1 ornithine decarboxylase 1
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PSIP1 PC4 and SFRS1 interacting protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TYMS thymidylate synthetase