BRD-K48576794_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K48576794_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CES1 carboxylesterase 1
CLU clusterin
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
ERP29 endoplasmic reticulum protein 29
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ITGB5 integrin, beta 5
KDM3A lysine (K)-specific demethylase 3A
KYNU kynureninase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PGD phosphogluconate dehydrogenase
PGLS 6-phosphogluconolactonase
PIR pirin (iron-binding nuclear protein)
RAP1GAP RAP1 GTPase activating protein
RIT1 Ras-like without CAAX 1
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPG20 spastic paraplegia 20 (Troyer syndrome)
SQSTM1 sequestosome 1
TALDO1 transaldolase 1
TKT transketolase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CA2 carbonic anhydrase II
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
COL3A1 collagen, type III, alpha 1
DCN decorin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ESR1 estrogen receptor 1
FHL2 four and a half LIM domains 2
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
ISOC1 isochorismatase domain containing 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100505650 uncharacterized LOC100505650
LOXL1 lysyl oxidase-like 1
LUM lumican
MECOM MDS1 and EVI1 complex locus
MUC1 mucin 1, cell surface associated
NCALD neurocalcin delta
PKP2 plakophilin 2
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAI14 retinoic acid induced 14
RFTN1 raftlin, lipid raft linker 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNX10 sorting nexin 10
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
STIP1 stress-induced phosphoprotein 1
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCAN versican
ZNF395 zinc finger protein 395