BRD-K48488978_YM-201636_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K48488978_YM-201636_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
APOD apolipoprotein D
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC3 chloride intracellular channel 3
CTSH cathepsin H
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNTT DNA nucleotidylexotransferase
DRAM1 DNA-damage regulated autophagy modulator 1
EZR ezrin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB29 RAB29, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SERINC5 serine incorporator 5
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
STK26 serine/threonine protein kinase 26
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CHEK2 checkpoint kinase 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
COTL1 coactosin-like F-actin binding protein 1
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM46A family with sequence similarity 46, member A
FCGBP Fc fragment of IgG binding protein
HIST1H2BC histone cluster 1, H2bc
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
KLF4 Kruppel-like factor 4 (gut)
MT1E metallothionein 1E
MYCBP MYC binding protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
ODC1 ornithine decarboxylase 1
PIH1D1 PIH1 domain containing 1
PLAT plasminogen activator, tissue
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)