BRD-K48488978_YM-201636_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K48488978_YM-201636_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
BPIFA1 BPI fold containing family A, member 1
C5 complement component 5
CES1 carboxylesterase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IL17RB interleukin 17 receptor B
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEFH neurofilament, heavy polypeptide
NMRK1 nicotinamide riboside kinase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PROM1 prominin 1
PSAP prosaposin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RABGAP1L RAB GTPase activating protein 1-like
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TF transferrin
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNS3 tensin 3
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC42 cell division cycle 42
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN7 claudin 7
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CXADR coxsackie virus and adenovirus receptor
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP6 dual specificity phosphatase 6
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
HOXB7 homeobox B7
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
KRT18 keratin 18, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP9 matrix metallopeptidase 9
MRPS28 mitochondrial ribosomal protein S28
MYCBP MYC binding protein
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
ODC1 ornithine decarboxylase 1
PA2G4 proliferation-associated 2G4, 38kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRM spermidine synthase
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
UBE2C ubiquitin-conjugating enzyme E2C
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L1 ZFP36 ring finger protein-like 1