BRD-K48488978_YM-201636_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K48488978_YM-201636_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
AOX1 aldehyde oxidase 1
ARL4C ADP-ribosylation factor-like 4C
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASS1 argininosuccinate synthase 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
C14ORF1 chromosome 14 open reading frame 1
CAST calpastatin
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSTB cystatin B (stefin B)
CTSA cathepsin A
CTSB cathepsin B
CTSK cathepsin K
CTSL cathepsin L
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EPN2 epsin 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
LDB3 LIM domain binding 3
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RAB29 RAB29, member RAS oncogene family
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDCBP syndecan binding protein (syntenin)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SVIL supervillin
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI2 tissue factor pathway inhibitor 2
TGM4 transglutaminase 4
TKT transketolase
TM7SF2 transmembrane 7 superfamily member 2
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
VAT1 vesicle amine transport 1
VCAN versican
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AREG amphiregulin
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CD24 CD24 molecule
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CERS6 ceramide synthase 6
CORO1A coronin, actin binding protein, 1A
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DEFA4 defensin, alpha 4, corticostatin
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
GATA3 GATA binding protein 3
GMFG glia maturation factor, gamma
GOLT1B golgi transport 1B
HCAR3 hydroxycarboxylic acid receptor 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HMG20B high mobility group 20B
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LRMP lymphoid-restricted membrane protein
MEF2C myocyte enhancer factor 2C
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NXT2 nuclear transport factor 2-like export factor 2
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SORBS3 sorbin and SH3 domain containing 3
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TMSB15A thymosin beta 15a
TSPAN13 tetraspanin 13