BRD-K47983010_BX-795_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K47983010_BX-795_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP2 amyloid beta (A4) precursor-like protein 2
BTG3 BTG family, member 3
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNN3 calponin 3, acidic
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
FAM129A family with sequence similarity 129, member A
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
GPX7 glutathione peroxidase 7
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KLF6 Kruppel-like factor 6
LITAF lipopolysaccharide-induced TNF factor
MELK maternal embryonic leucine zipper kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PSPH phosphoserine phosphatase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPA2 surfactant protein A2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALOX5 arachidonate 5-lipoxygenase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BLNK B-cell linker
C7 complement component 7
CALR calreticulin
CD24 CD24 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHD9 chromodomain helicase DNA binding protein 9
CLC Charcot-Leyden crystal galectin
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DACH1 dachshund family transcription factor 1
DES desmin
DLK1 delta-like 1 homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FABP4 fatty acid binding protein 4, adipocyte
FZD10 frizzled class receptor 10
GPRC5A G protein-coupled receptor, class C, group 5, member A
GYG1 glycogenin 1
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PBX1 pre-B-cell leukemia homeobox 1
PLK1 polo-like kinase 1
PLN phospholamban
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
RIPK4 receptor-interacting serine-threonine kinase 4
RNASE3 ribonuclease, RNase A family, 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STXBP2 syntaxin binding protein 2
TLR4 toll-like receptor 4
TMEM5 transmembrane protein 5
TOX3 TOX high mobility group box family member 3
TSPAN12 tetraspanin 12
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF423 zinc finger protein 423