BRD-K47983010_BX-795_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K47983010_BX-795_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
BAMBI BMP and activin membrane-bound inhibitor
BCL2A1 BCL2-related protein A1
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CCL20 chemokine (C-C motif) ligand 20
CD52 CD52 molecule
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
FAM63A family with sequence similarity 63, member A
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
HIST1H2AC histone cluster 1, H2ac
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IL32 interleukin 32
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KYNU kynureninase
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PLD3 phospholipase D family, member 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SFTPB surfactant protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAP2 signal transducing adaptor family member 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRAF1 TNF receptor-associated factor 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WSB1 WD repeat and SOCS box containing 1
XAF1 XIAP associated factor 1
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
ABHD11 abhydrolase domain containing 11
ACTN1 actinin, alpha 1
AHNAK2 AHNAK nucleoprotein 2
ANXA1 annexin A1
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C5 complement component 5
CALB1 calbindin 1, 28kDa
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKB creatine kinase, brain
CLTB clathrin, light chain B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DHFR dihydrofolate reductase
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HMGN3 high mobility group nucleosomal binding domain 3
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
LIG1 ligase I, DNA, ATP-dependent
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100505650 uncharacterized LOC100505650
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
PBK PDZ binding kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PROM1 prominin 1
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
SCARB1 scavenger receptor class B, member 1
SCGB2A1 secretoglobin, family 2A, member 1
SET SET nuclear proto-oncogene
SHCBP1 SHC SH2-domain binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SRSF3 serine/arginine-rich splicing factor 3
TGFBR3 transforming growth factor, beta receptor III
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRDV3 T cell receptor delta variable 3
TRMT5 tRNA methyltransferase 5
TUBA4A tubulin, alpha 4a
UBE2S ubiquitin-conjugating enzyme E2S
VAV3 vav 3 guanine nucleotide exchange factor
ZWINT ZW10 interacting kinetochore protein