BRD-K47659338_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K47659338_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
AMDHD2 amidohydrolase domain containing 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAG2 BCL2-associated athanogene 2
C6ORF48 chromosome 6 open reading frame 48
CD320 CD320 molecule
CES1 carboxylesterase 1
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP22 dual specificity phosphatase 22
EGR3 early growth response 3
EML3 echinoderm microtubule associated protein like 3
F5 coagulation factor V (proaccelerin, labile factor)
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HOXC6 homeobox C6
INTS3 integrator complex subunit 3
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF14 kinesin family member 14
LY75 lymphocyte antigen 75
MYO10 myosin X
NOV nephroblastoma overexpressed
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPN3 opsin 3
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA1A phospholipase A1 member A
PLCB4 phospholipase C, beta 4
PRUNE prune exopolyphosphatase
PURA purine-rich element binding protein A
QPCT glutaminyl-peptide cyclotransferase
RBPMS RNA binding protein with multiple splicing
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORD sorbitol dehydrogenase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TNIK TRAF2 and NCK interacting kinase
TPD52L1 tumor protein D52-like 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3
ZMYND8 zinc finger, MYND-type containing 8
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ATF3 activating transcription factor 3
C1ORF116 chromosome 1 open reading frame 116
C1QA complement component 1, q subcomponent, A chain
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CANT1 calcium activated nucleotidase 1
CD24 CD24 molecule
CD9 CD9 molecule
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
EFS embryonal Fyn-associated substrate
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD6 FXYD domain containing ion transport regulator 6
GATA3 GATA binding protein 3
HBB hemoglobin, beta
HOPX HOP homeobox
HOXD1 homeobox D1
IER3 immediate early response 3
ITGA6 integrin, alpha 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MFAP2 microfibrillar-associated protein 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MT1E metallothionein 1E
MTERF3 mitochondrial transcription termination factor 3
MUC2 mucin 2, oligomeric mucus/gel-forming
NLRP2 NLR family, pyrin domain containing 2
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI1 pellino E3 ubiquitin protein ligase 1
PTHLH parathyroid hormone-like hormone
PXDN peroxidasin
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1B small proline-rich protein 1B
STAB1 stabilin 1
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM45A transmembrane protein 45A
TNNT1 troponin T type 1 (skeletal, slow)
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TYROBP TYRO protein tyrosine kinase binding protein
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon