BRD-K47635719_Dexamethasone acetate_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

220 genes differentially expressed following the BRD-K47635719_Dexamethasone acetate_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
ALDOB aldolase B, fructose-bisphosphate
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASPN asporin
ASS1 argininosuccinate synthase 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CDV3 CDV3 homolog (mouse)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES2 carboxylesterase 2
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
CTBP2 C-terminal binding protein 2
CTSK cathepsin K
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ELANE elastase, neutrophil expressed
EZR ezrin
FGFR2 fibroblast growth factor receptor 2
FKBP5 FK506 binding protein 5
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTA1 glutathione S-transferase alpha 1
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KL klotho
KLF9 Kruppel-like factor 9
LTF lactotransferrin
MAOA monoamine oxidase A
MGAM maltase-glucoamylase
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSRA methionine sulfoxide reductase A
MT1F metallothionein 1F
MT1M metallothionein 1M
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PER1 period circadian clock 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POU2AF1 POU class 2 associating factor 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRR15L proline rich 15-like
PRTN3 proteinase 3
RAB25 RAB25, member RAS oncogene family
RGCC regulator of cell cycle
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBXA2R thromboxane A2 receptor
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM176B transmembrane protein 176B
TNIP1 TNFAIP3 interacting protein 1
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
VNN1 vanin 1
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD99 CD99 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CST3 cystatin C
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHB2 EPH receptor B2
ETV5 ets variant 5
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FHL2 four and a half LIM domains 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GAS7 growth arrest-specific 7
GLIPR1 GLI pathogenesis-related 1
GPATCH8 G patch domain containing 8
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB11 heat shock protein family B (small), member 11
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
LEF1 lymphoid enhancer-binding factor 1
LPAR1 lysophosphatidic acid receptor 1
LYPD1 LY6/PLAUR domain containing 1
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MTF2 metal response element binding transcription factor 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY neuropeptide Y
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PRDX2 peroxiredoxin 2
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
S100A6 S100 calcium binding protein A6
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPAG16 sperm associated antigen 16
SPDEF SAM pointed domain containing ETS transcription factor
SYNJ2 synaptojanin 2
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS4 thrombospondin 4
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXNDC9 thioredoxin domain containing 9
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B
WBP5 WW domain binding protein 5
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2