BRD-K46692335_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K46692335_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C10ORF10 chromosome 10 open reading frame 10
CCND2 cyclin D2
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPE carboxypeptidase E
CTSK cathepsin K
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
EPYC epiphycan
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
INSIG1 insulin induced gene 1
KRT23 keratin 23, type I
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1F metallothionein 1F
MT1X metallothionein 1X
NPTX2 neuronal pentraxin II
NUAK1 NUAK family, SNF1-like kinase, 1
NVL nuclear VCP-like
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
PNMAL1 paraneoplastic Ma antigen family-like 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF167 ring finger protein 167
RTN2 reticulon 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SNAI2 snail family zinc finger 2
SYT1 synaptotagmin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
AGR2 anterior gradient 2
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM46A family with sequence similarity 46, member A
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIP1 huntingtin interacting protein 1
IL6ST interleukin 6 signal transducer
MYB v-myb avian myeloblastosis viral oncogene homolog
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPR3 natriuretic peptide receptor 3
NRIP1 nuclear receptor interacting protein 1
PLAC8 placenta-specific 8
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SCARB2 scavenger receptor class B, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBX2 T-box 2
TNNC1 troponin C type 1 (slow)
TPM4 tropomyosin 4