BRD-K46678324_Rho-Kinase Inhibitor II_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K46678324_Rho-Kinase Inhibitor II_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL4A5 collagen, type IV, alpha 5
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL13 chemokine (C-X-C motif) ligand 13
DSTN destrin (actin depolymerizing factor)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FRZB frizzled-related protein
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
LAMP3 lysosomal-associated membrane protein 3
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA6 melanoma antigen family A6
MEST mesoderm specific transcript
MTSS1 metastasis suppressor 1
NPEPL1 aminopeptidase-like 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
SST somatostatin
THBD thrombomodulin
THBS1 thrombospondin 1
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TSPYL5 TSPY-like 5
ZFPM2 zinc finger protein, FOG family member 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADRB2 adrenoceptor beta 2, surface
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSB cathepsin B
FSTL1 follistatin-like 1
HBB hemoglobin, beta
IFRD2 interferon-related developmental regulator 2
LCN2 lipocalin 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
PLIN3 perilipin 3
PTGES prostaglandin E synthase
RRAGD Ras-related GTP binding D
RUNX1 runt-related transcription factor 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCEL sciellin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSPAN8 tetraspanin 8