BRD-K46419649_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K46419649_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAA1 acetyl-CoA acyltransferase 1
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMACR alpha-methylacyl-CoA racemase
ARMT1 acidic residue methyltransferase 1
ASS1 argininosuccinate synthase 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BLVRB biliverdin reductase B
BRD8 bromodomain containing 8
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GATA2 GATA binding protein 2
GPX4 glutathione peroxidase 4
HBP1 HMG-box transcription factor 1
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSDL2 hydroxysteroid dehydrogenase like 2
HSPB1 heat shock 27kDa protein 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
NUSAP1 nucleolar and spindle associated protein 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSR2 odd-skipped related transciption factor 2
PDZK1 PDZ domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
POR P450 (cytochrome) oxidoreductase
PPL periplakin
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RXRA retinoid X receptor, alpha
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SUOX sulfite oxidase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADAM19 ADAM metallopeptidase domain 19
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
BOP1 block of proliferation 1
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
CCDC86 coiled-coil domain containing 86
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHD7 chromodomain helicase DNA binding protein 7
CNN3 calponin 3, acidic
CPE carboxypeptidase E
CSNK1E casein kinase 1, epsilon
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKC1 dyskeratosis congenita 1, dyskerin
DPH2 DPH2 homolog (S. cerevisiae)
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
E2F5 E2F transcription factor 5, p130-binding
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM3C family with sequence similarity 3, member C
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPM6B glycoprotein M6B
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HOMER1 homer scaffolding protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL1RAP interleukin 1 receptor accessory protein
INPP1 inositol polyphosphate-1-phosphatase
IPO4 importin 4
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KIAA0020 KIAA0020
KIAA0226L KIAA0226-like
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MINA MYC induced nuclear antigen
MMP9 matrix metallopeptidase 9
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MT1X metallothionein 1X
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NT5E 5'-nucleotidase, ecto (CD73)
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK1IP1 PAK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PNN pinin, desmosome associated protein
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTRH2 peptidyl-tRNA hydrolase 2
PUS7 pseudouridylate synthase 7 (putative)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
RPP40 ribonuclease P/MRP 40kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC35F2 solute carrier family 35, member F2
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
STC1 stanniocalcin 1
SV2A synaptic vesicle glycoprotein 2A
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TEX10 testis expressed 10
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TUBB2B tubulin, beta 2B class IIb
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36L2 ZFP36 ring finger protein-like 2