BRD-K46419649_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K46419649_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAT1 acetyl-CoA acetyltransferase 1
AHNAK AHNAK nucleoprotein
BLMH bleomycin hydrolase
CYTH1 cytohesin 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
GPER1 G protein-coupled estrogen receptor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INHBB inhibin, beta B
IQCK IQ motif containing K
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP3 latent transforming growth factor beta binding protein 3
MAP7 microtubule-associated protein 7
MYH10 myosin, heavy chain 10, non-muscle
NUPR1 nuclear protein, transcriptional regulator, 1
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PRAME preferentially expressed antigen in melanoma
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB40B RAB40B, member RAS oncogene family
RAD51C RAD51 paralog C
RHOBTB3 Rho-related BTB domain containing 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AUTS2 autism susceptibility candidate 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
INPP1 inositol polyphosphate-1-phosphatase
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT14 keratin 14, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP16 NOP16 nucleolar protein
NRG1 neuregulin 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTPRK protein tyrosine phosphatase, receptor type, K
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A6 S100 calcium binding protein A6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
STK26 serine/threonine protein kinase 26
SYBU syntabulin (syntaxin-interacting)
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOR1A torsin family 1, member A (torsin A)
TRIB1 tribbles pseudokinase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)