BRD-K46373671_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K46373671_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AEBP1 AE binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CCND2 cyclin D2
CD52 CD52 molecule
CDK12 cyclin-dependent kinase 12
CEP57 centrosomal protein 57kDa
CFB complement factor B
CLEC2B C-type lectin domain family 2, member B
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
DDIT4 DNA-damage-inducible transcript 4
ECM1 extracellular matrix protein 1
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ISYNA1 inositol-3-phosphate synthase 1
LAPTM5 lysosomal protein transmembrane 5
LASP1 LIM and SH3 protein 1
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP11 matrix metallopeptidase 11
MPPED2 metallophosphoesterase domain containing 2
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
PCGF2 polycomb group ring finger 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PLIN2 perilipin 2
PRAF2 PRA1 domain family, member 2
PRAME preferentially expressed antigen in melanoma
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35E2B solute carrier family 35, member E2B
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TFF3 trefoil factor 3 (intestinal)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17

decreased expression

Symbol Name
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD36 CD36 molecule (thrombospondin receptor)
CHN1 chimerin 1
CHSY1 chondroitin sulfate synthase 1
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
COL5A2 collagen, type V, alpha 2
CST3 cystatin C
CXCL13 chemokine (C-X-C motif) ligand 13
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPT dermatopontin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
PDGFA platelet-derived growth factor alpha polypeptide
PMM2 phosphomannomutase 2
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TAGLN transgelin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TSPYL5 TSPY-like 5
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)