BRD-K46056750_AZD-7762_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K46056750_AZD-7762_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
ALDOC aldolase C, fructose-bisphosphate
B3GNT1
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C3 complement component 3
CCNG2 cyclin G2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CTSF cathepsin F
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
ETFB electron-transfer-flavoprotein, beta polypeptide
FADS1 fatty acid desaturase 1
FAM8A1 family with sequence similarity 8, member A1
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IRS2 insulin receptor substrate 2
ITM2C integral membrane protein 2C
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LMO3 LIM domain only 3 (rhombotin-like 2)
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MXRA5 matrix-remodelling associated 5
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PRKCQ protein kinase C, theta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SALL2 spalt-like transcription factor 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SSPN sarcospan
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM59 transmembrane protein 59
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TST thiosulfate sulfurtransferase (rhodanese)
WBP5 WW domain binding protein 5
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
AURKB aurora kinase B
BOP1 block of proliferation 1
BZW2 basic leucine zipper and W2 domains 2
CALML5 calmodulin-like 5
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLDN3 claudin 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGA1 high mobility group AT-hook 1
KIAA0020 KIAA0020
KRT14 keratin 14, type I
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPIF peptidylprolyl isomerase F
PUS7 pseudouridylate synthase 7 (putative)
RANBP1 RAN binding protein 1
RCC1 regulator of chromosome condensation 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SOAT1 sterol O-acyltransferase 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
TPX2 TPX2, microtubule-associated
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein