BRD-K46056750_AZD-7762_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

45 genes differentially expressed following the BRD-K46056750_AZD-7762_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
INSR insulin receptor
IRS2 insulin receptor substrate 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTX3 pentraxin 3, long
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SRSF6 serine/arginine-rich splicing factor 6
TBX3 T-box 3
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
CALML5 calmodulin-like 5
CCL4 chemokine (C-C motif) ligand 4
CCNA2 cyclin A2
CCNE2 cyclin E2
CELF2 CUGBP, Elav-like family member 2
CLEC2B C-type lectin domain family 2, member B
CSRP2 cysteine and glycine-rich protein 2
CST7 cystatin F (leukocystatin)
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFNG interferon, gamma
IL4R interleukin 4 receptor
LRRC17 leucine rich repeat containing 17
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PVRL3 poliovirus receptor-related 3
RRM2 ribonucleotide reductase M2
S100A6 S100 calcium binding protein A6
SCGB2A1 secretoglobin, family 2A, member 1
SPP1 secreted phosphoprotein 1
VCAM1 vascular cell adhesion molecule 1