BRD-K46056750_AZD-7762_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K46056750_AZD-7762_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
BASP1 brain abundant, membrane attached signal protein 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CBR3 carbonyl reductase 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEFB1 defensin, beta 1
DOK5 docking protein 5
EMX2 empty spiracles homeobox 2
FGL2 fibrinogen-like 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA5 homeobox A5
HSPB8 heat shock 22kDa protein 8
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
LXN latexin
METTL7A methyltransferase like 7A
MYB v-myb avian myeloblastosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE1A phosphodiesterase 1A, calmodulin-dependent
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRUNE2 prune homolog 2 (Drosophila)
PTPRD protein tyrosine phosphatase, receptor type, D
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RUFY3 RUN and FYVE domain containing 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
STAR steroidogenic acute regulatory protein
TCF4 transcription factor 4
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
VCAN versican
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ARL4C ADP-ribosylation factor-like 4C
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CDK6 cyclin-dependent kinase 6
COPA coatomer protein complex, subunit alpha
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DST dystonin
EPAS1 endothelial PAS domain protein 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HMGA2 high mobility group AT-hook 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
IRS1 insulin receptor substrate 1
ITGA6 integrin, alpha 6
KRT14 keratin 14, type I
LITAF lipopolysaccharide-induced TNF factor
MMD monocyte to macrophage differentiation-associated
NBPF10 neuroblastoma breakpoint family, member 10
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NRIP1 nuclear receptor interacting protein 1
NXN nucleoredoxin
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRRC2C proline-rich coiled-coil 2C
PTHLH parathyroid hormone-like hormone
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT3 sirtuin 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SON SON DNA binding protein
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPD52 tumor protein D52
TPR translocated promoter region, nuclear basket protein
TTC3 tetratricopeptide repeat domain 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2