BRD-K46056750_AZD-7762_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K46056750_AZD-7762_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACYP2 acylphosphatase 2, muscle type
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
CAPN1 calpain 1, (mu/I) large subunit
CD14 CD14 molecule
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CLDN1 claudin 1
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DES desmin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNA1 ephrin-A1
EIF4A2 eukaryotic translation initiation factor 4A2
FBLN1 fibulin 1
FBLN2 fibulin 2
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP8 GTP-binding protein 8 (putative)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
KRT13 keratin 13, type I
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
MUC1 mucin 1, cell surface associated
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAM peptidylglycine alpha-amidating monooxygenase
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRAME preferentially expressed antigen in melanoma
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS27L ribosomal protein S27-like
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SSR4 signal sequence receptor, delta
TMEM59 transmembrane protein 59
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
BMP2 bone morphogenetic protein 2
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CDC20 cell division cycle 20
CENPF centromere protein F, 350/400kDa
COL4A2 collagen, type IV, alpha 2
CTSZ cathepsin Z
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
EFHD1 EF-hand domain family, member D1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FGFR1 fibroblast growth factor receptor 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IQGAP2 IQ motif containing GTPase activating protein 2
JAG1 jagged 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NPTX1 neuronal pentraxin I
PDLIM5 PDZ and LIM domain 5
PRSS3 protease, serine, 3
RBMS1 RNA binding motif, single stranded interacting protein 1
RFTN1 raftlin, lipid raft linker 1
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TRIP13 thyroid hormone receptor interactor 13
XBP1 X-box binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1