BRD-K46056750_AZD-7762_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-K46056750_AZD-7762_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGA aspartylglucosaminidase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF3 activating transcription factor 3
AURKB aurora kinase B
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BRD2 bromodomain containing 2
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CAPN1 calpain 1, (mu/I) large subunit
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDCA4 cell division cycle associated 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPE centromere protein E, 312kDa
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLASRP CLK4-associating serine/arginine rich protein
CLK4 CDC-like kinase 4
CLPTM1 cleft lip and palate associated transmembrane protein 1
COCH cochlin
CPD carboxypeptidase D
CXCL5 chemokine (C-X-C motif) ligand 5
DAPK3 death-associated protein kinase 3
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DPP4 dipeptidyl-peptidase 4
EGR1 early growth response 1
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLA galactosidase, alpha
GOLGA8H golgin A8 family, member H
GPX4 glutathione peroxidase 4
GSTT1 glutathione S-transferase theta 1
H1FX H1 histone family, member X
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IGL immunoglobulin lambda locus
ITFG1 integrin alpha FG-GAP repeat containing 1
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0907 KIAA0907
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KLF5 Kruppel-like factor 5 (intestinal)
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LOC399491
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGAM maltase-glucoamylase
MUC1 mucin 1, cell surface associated
MYBPC1 myosin binding protein C, slow type
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NXF1 nuclear RNA export factor 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2A phosphatidic acid phosphatase type 2A
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRO protein tyrosine phosphatase, receptor type, O
RAD9A RAD9 homolog A (S. pombe)
RBM39 RNA binding motif protein 39
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRC2 arginine/serine-rich coiled-coil 2
RSRP1 arginine/serine-rich protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
TBC1D15 TBC1 domain family, member 15
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKTL1 transketolase-like 1
TM4SF4 transmembrane 4 L six family member 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM259 transmembrane protein 259
TNF tumor necrosis factor
TSPAN4 tetraspanin 4
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD200 CD200 molecule
CDCP1 CUB domain containing protein 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CELF2 CUGBP, Elav-like family member 2
CHSY1 chondroitin sulfate synthase 1
CNN3 calponin 3, acidic
COL5A1 collagen, type V, alpha 1
CPOX coproporphyrinogen oxidase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYTH1 cytohesin 1
DESI2 desumoylating isopeptidase 2
DPYSL2 dihydropyrimidinase-like 2
DUSP7 dual specificity phosphatase 7
DYNLT1 dynein, light chain, Tctex-type 1
ECHDC3 enoyl CoA hydratase domain containing 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHB2 EPH receptor B2
ESRP1 epithelial splicing regulatory protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FNBP1 formin binding protein 1
FXYD5 FXYD domain containing ion transport regulator 5
GATA6 GATA binding protein 6
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTO1 glutathione S-transferase omega 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEPH hephaestin
HSPA8 heat shock 70kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MBNL1 muscleblind-like splicing regulator 1
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MSN moesin
MUC16 mucin 16, cell surface associated
MX1 MX dynamin-like GTPase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NES nestin
NPAS2 neuronal PAS domain protein 2
OLFM4 olfactomedin 4
PBX3 pre-B-cell leukemia homeobox 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PMP22 peripheral myelin protein 22
PODXL podocalyxin-like
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
PTBP3 polypyrimidine tract binding protein 3
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TMEM123 transmembrane protein 123
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TRAF5 TNF receptor-associated factor 5
TRIB2 tribbles pseudokinase 2
TRIM14 tripartite motif containing 14
TRIM2 tripartite motif containing 2
TUBB6 tubulin, beta 6 class V
USP6NL USP6 N-terminal like
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR77 WD repeat domain 77
WWTR1 WW domain containing transcription regulator 1