BRD-K46056750_AZD-7762_HCC515_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K46056750_AZD-7762_HCC515_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADGRG2 adhesion G protein-coupled receptor G2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF3 activating transcription factor 3
AURKB aurora kinase B
BAG3 BCL2-associated athanogene 3
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CCNB2 cyclin B2
CCNG2 cyclin G2
CDCA4 cell division cycle associated 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP6 charged multivesicular body protein 6
CKS2 CDC28 protein kinase regulatory subunit 2
CLK4 CDC-like kinase 4
COL9A3 collagen, type IX, alpha 3
CST3 cystatin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KIAA0907 KIAA0907
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGAM maltase-glucoamylase
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPD2 non-SMC condensin I complex, subunit D2
NDC80 NDC80 kinetochore complex component
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUSAP1 nucleolar and spindle associated protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PILRB paired immunoglobin-like type 2 receptor beta
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSPC1 paraspeckle component 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
SYNGR3 synaptogyrin 3
TESC tescalcin
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN4 tetraspanin 4
TSPYL2 TSPY-like 2
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD200 CD200 molecule
CDC45 cell division cycle 45
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CERS6 ceramide synthase 6
CFB complement factor B
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
FABP4 fatty acid binding protein 4, adipocyte
FAM114A1 family with sequence similarity 114, member A1
FGG fibrinogen gamma chain
FHOD3 formin homology 2 domain containing 3
FXYD5 FXYD domain containing ion transport regulator 5
GPI glucose-6-phosphate isomerase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP3 insulin-like growth factor binding protein 3
JAG1 jagged 1
KRT19 keratin 19, type I
LASP1 LIM and SH3 protein 1
LBH limb bud and heart development
MLPH melanophilin
MOCOS molybdenum cofactor sulfurase
NEBL nebulette
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PSD3 pleckstrin and Sec7 domain containing 3
PTPRO protein tyrosine phosphatase, receptor type, O
RGS4 regulator of G-protein signaling 4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10