BRD-K46056750_AZD-7762_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K46056750_AZD-7762_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DST dystonin
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EPCAM epithelial cell adhesion molecule
FAM46A family with sequence similarity 46, member A
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
GOLGA8H golgin A8 family, member H
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
ISYNA1 inositol-3-phosphate synthase 1
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
NEFL neurofilament, light polypeptide
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RCAN2 regulator of calcineurin 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPP38 ribonuclease P/MRP 38kDa subunit
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQRDL sulfide quinone reductase-like (yeast)
STAT1 signal transducer and activator of transcription 1, 91kDa
TBX2 T-box 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM30B transmembrane protein 30B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX thymocyte selection-associated high mobility group box
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCND1 cyclin D1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEP170 centrosomal protein 170kDa
CHD7 chromodomain helicase DNA binding protein 7
CNN3 calponin 3, acidic
EPHB2 EPH receptor B2
FLNB filamin B, beta
FN1 fibronectin 1
GLIPR1 GLI pathogenesis-related 1
HAS2 hyaluronan synthase 2
HOXA5 homeobox A5
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IL6ST interleukin 6 signal transducer
ITGA6 integrin, alpha 6
LOX lysyl oxidase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MOK MOK protein kinase
NEK7 NIMA-related kinase 7
PDLIM5 PDZ and LIM domain 5
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
QPRT quinolinate phosphoribosyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNS1 tensin 1
TRAM2 translocation associated membrane protein 2
VCAN versican
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZBTB18 zinc finger and BTB domain containing 18
ZMIZ1 zinc finger, MIZ-type containing 1