BRD-K46056750_AZD-7762_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K46056750_AZD-7762_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTA2 actin, alpha 2, smooth muscle, aorta
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAX BCL2-associated X protein
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EGR1 early growth response 1
EPS8L2 EPS8-like 2
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GOLGA8B golgin A8 family, member B
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INHBB inhibin, beta B
INPP1 inositol polyphosphate-1-phosphatase
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIZ kizuna centrosomal protein
LETMD1 LETM1 domain containing 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PTBP2 polypyrimidine tract binding protein 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RPS27L ribosomal protein S27-like
RRAD Ras-related associated with diabetes
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STK38L serine/threonine kinase 38 like
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53I3 tumor protein p53 inducible protein 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM22 tripartite motif containing 22
XPC xeroderma pigmentosum, complementation group C
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBFB core-binding factor, beta subunit
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLC Charcot-Leyden crystal galectin
COL4A2 collagen, type IV, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNASE1L3 deoxyribonuclease I-like 3
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
FAM3C family with sequence similarity 3, member C
FEN1 flap structure-specific endonuclease 1
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP1 insulin-like growth factor binding protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
ITGB6 integrin, beta 6
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LIN28A lin-28 homolog A (C. elegans)
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRGN neurogranin (protein kinase C substrate, RC3)
OIP5 Opa interacting protein 5
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAD51 RAD51 recombinase
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMPO thymopoietin
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)