BRD-K46056750_AZD-7762_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K46056750_AZD-7762_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1R complement component 1, r subcomponent
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHPT1 choline phosphotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CTH cystathionine gamma-lyase
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSPT2 G1 to S phase transition 2
HIST1H2BK histone cluster 1, H2bk
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
ISCU iron-sulfur cluster assembly enzyme
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLK2 kallikrein-related peptidase 2
LINC00341 long intergenic non-protein coding RNA 341
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
NKX3-1 NK3 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCDH9 protocadherin 9
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
RHOB ras homolog family member B
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TSPAN6 tetraspanin 6
YBX3 Y box binding protein 3
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANXA3 annexin A3
APOA2 apolipoprotein A-II
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
C1ORF106 chromosome 1 open reading frame 106
C2CD2 C2 calcium-dependent domain containing 2
CAST calpastatin
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CHGB chromogranin B
CHN1 chimerin 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENOPH1 enolase-phosphatase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
FSCN1 fascin actin-bundling protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
IL1RN interleukin 1 receptor antagonist
KLK10 kallikrein-related peptidase 10
KRT16 keratin 16, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
MALL mal, T-cell differentiation protein-like
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PODXL podocalyxin-like
RCAN2 regulator of calcineurin 2
RGS4 regulator of G-protein signaling 4
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TPBG trophoblast glycoprotein
TPM4 tropomyosin 4