BRD-K45842176_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K45842176_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA12 carbonic anhydrase XII
CBS cystathionine-beta-synthase
CD52 CD52 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL3A1 collagen, type III, alpha 1
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
FAM69A family with sequence similarity 69, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FST follistatin
GLTSCR2 glioma tumor suppressor candidate region gene 2
GMPR guanosine monophosphate reductase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IGFBP6 insulin-like growth factor binding protein 6
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
JCHAIN joining chain of multimeric IgA and IgM
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP7 microtubule-associated protein 7
MBOAT7 membrane bound O-acyltransferase domain containing 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
NKX3-1 NK3 homeobox 1
NMU neuromedin U
NR1H2 nuclear receptor subfamily 1, group H, member 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PSG5 pregnancy specific beta-1-glycoprotein 5
PTN pleiotrophin
RGCC regulator of cell cycle
RPS5 ribosomal protein S5
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SHB Src homology 2 domain containing adaptor protein B
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
VSNL1 visinin-like 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
C7 complement component 7
CBX6 chromobox homolog 6
CD24 CD24 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHL1 cell adhesion molecule L1-like
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FLRT2 fibronectin leucine rich transmembrane protein 2
FRZB frizzled-related protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSTM3 glutathione S-transferase mu 3 (brain)
GYG1 glycogenin 1
HOXC6 homeobox C6
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA3 melanoma antigen family A3
MMP9 matrix metallopeptidase 9
NFIB nuclear factor I/B
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKCH protein kinase C, eta
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
RNF167 ring finger protein 167
SLC35F2 solute carrier family 35, member F2
STOM stomatin
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
WWTR1 WW domain containing transcription regulator 1
ZYX zyxin