BRD-K45818044_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K45818044_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
ELANE elastase, neutrophil expressed
FADS1 fatty acid desaturase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC38A1 solute carrier family 38, member 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
BTG3 BTG family, member 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXYD3 FXYD domain containing ion transport regulator 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
KDM5D lysine (K)-specific demethylase 5D
MSH6 mutS homolog 6
NOTCH1 notch 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
ZNF586 zinc finger protein 586