BRD-K45735142_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K45735142_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BASP1 brain abundant, membrane attached signal protein 1
BID BH3 interacting domain death agonist
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
CYLD cylindromatosis (turban tumor syndrome)
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GREB1 growth regulation by estrogen in breast cancer 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
LXN latexin
MAOA monoamine oxidase A
MSLN mesothelin
MSMB microseminoprotein, beta-
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
PCP4 Purkinje cell protein 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QPCT glutaminyl-peptide cyclotransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SPON1 spondin 1, extracellular matrix protein
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TARP TCR gamma alternate reading frame protein
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CYB5A cytochrome b5 type A (microsomal)
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZR ezrin
FAM46A family with sequence similarity 46, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTP1 glutathione S-transferase pi 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGKC immunoglobulin kappa constant
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0125 KIAA0125
KRT14 keratin 14, type I
NUP88 nucleoporin 88kDa
PDLIM1 PDZ and LIM domain 1
PFKP phosphofructokinase, platelet
PFN2 profilin 2
POSTN periostin, osteoblast specific factor
PRDX4 peroxiredoxin 4
PTN pleiotrophin
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TP53 tumor protein p53
TPM4 tropomyosin 4
TSPAN3 tetraspanin 3
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZIC1 Zic family member 1
ZNF395 zinc finger protein 395