BRD-K45735142_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K45735142_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADGRG6 adhesion G protein-coupled receptor G6
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FBP1 fructose-1,6-bisphosphatase 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
LDOC1 leucine zipper, down-regulated in cancer 1
MEST mesoderm specific transcript
MICALL1 MICAL-like 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MTMR11 myotubularin related protein 11
MYRF myelin regulatory factor
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
OSBPL10 oxysterol binding protein-like 10
PDE10A phosphodiesterase 10A
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCL1 phospholipase C-like 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
REG1A regenerating islet-derived 1 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
SGK1 serum/glucocorticoid regulated kinase 1
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAR steroidogenic acute regulatory protein
TFF1 trefoil factor 1
TLE4 transducin-like enhancer of split 4
WT1 Wilms tumor 1

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
BAG2 BCL2-associated athanogene 2
C6ORF62 chromosome 6 open reading frame 62
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNPY3 canopy FGF signaling regulator 3
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
GPM6B glycoprotein M6B
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL13RA2 interleukin 13 receptor, alpha 2
ISG15 ISG15 ubiquitin-like modifier
KRT5 keratin 5, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LPL lipoprotein lipase
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MCOLN1 mucolipin 1
MYO1B myosin IB
PERP PERP, TP53 apoptosis effector
PIP prolactin-induced protein
QDPR quinoid dihydropteridine reductase
RBP1 retinol binding protein 1, cellular
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRIO trio Rho guanine nucleotide exchange factor
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1