BRD-K45542213_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K45542213_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIDA axin interactor, dorsalization associated
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CCNA1 cyclin A1
CD200 CD200 molecule
CD24 CD24 molecule
CD52 CD52 molecule
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXCL11 chemokine (C-X-C motif) ligand 11
DCN decorin
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DSC2 desmocollin 2
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EML1 echinoderm microtubule associated protein like 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
H2BFS H2B histone family, member S (pseudogene)
HEBP2 heme binding protein 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IL13RA1 interleukin 13 receptor, alpha 1
IPO13 importin 13
KLK5 kallikrein-related peptidase 5
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MYO1B myosin IB
ORC1 origin recognition complex, subunit 1
PDE10A phosphodiesterase 10A
PDLIM3 PDZ and LIM domain 3
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A2 solute carrier family 38, member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBPL1 TBP-like 1
TCEAL2 transcription elongation factor A (SII)-like 2
TDO2 tryptophan 2,3-dioxygenase
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TRIM36 tripartite motif containing 36
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANXA5 annexin A5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAD BCL2-associated agonist of cell death
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CHPT1 choline phosphotransferase 1
CSNK1E casein kinase 1, epsilon
CST3 cystatin C
CTSH cathepsin H
CTTN cortactin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM46A family with sequence similarity 46, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
HOXB7 homeobox B7
HOXC6 homeobox C6
IRS2 insulin receptor substrate 2
JARID2 jumonji, AT rich interactive domain 2
LTBP3 latent transforming growth factor beta binding protein 3
MLEC malectin
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTGES prostaglandin E synthase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TNPO1 transportin 1
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
WBSCR22 Williams Beuren syndrome chromosome region 22
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3