BRD-K45435259_r(+)-sch-23390_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

182 genes differentially expressed following the BRD-K45435259_r(+)-sch-23390_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CALR calreticulin
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC5A C-type lectin domain family 5, member A
CPA3 carboxypeptidase A3 (mast cell)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIP2 cysteine-rich protein 2
CST6 cystatin E/M
CTSZ cathepsin Z
ELANE elastase, neutrophil expressed
ENG endoglin
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
FSCN1 fascin actin-bundling protein 1
FST follistatin
FXYD5 FXYD domain containing ion transport regulator 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HOMER3 homer scaffolding protein 3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPG2 heparan sulfate proteoglycan 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LOC100286895 cell division cycle 27 homolog pseudogene
LTF lactotransferrin
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NUCB1 nucleobindin 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLAU plasminogen activator, urokinase
PLIN3 perilipin 3
PLVAP plasmalemma vesicle associated protein
POR P450 (cytochrome) oxidoreductase
PRTN3 proteinase 3
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RASA4 RAS p21 protein activator 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCD5 stearoyl-CoA desaturase 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM4 tropomyosin 4
TTN titin
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ABI1 abl-interactor 1
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFDP1 craniofacial development protein 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CREBL2 cAMP responsive element binding protein-like 2
CTSK cathepsin K
CXCL13 chemokine (C-X-C motif) ligand 13
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DLD dihydrolipoamide dehydrogenase
DMXL2 Dmx-like 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENOPH1 enolase-phosphatase 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
FAM13B family with sequence similarity 13, member B
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP8 GTP-binding protein 8 (putative)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPB11 heat shock protein family B (small), member 11
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
KIF2A kinesin heavy chain member 2A
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LRRC16A leucine rich repeat containing 16A
LUC7L3 LUC7-like 3 (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH10 myosin, heavy chain 10, non-muscle
NOTCH2NL notch 2 N-terminal like
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OAT ornithine aminotransferase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40B RAB40B, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNF167 ring finger protein 167
RPIA ribose 5-phosphate isomerase A
RRP1B ribosomal RNA processing 1B
SAMD4A sterile alpha motif domain containing 4A
SC5D sterol-C5-desaturase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMS spermine synthase
SRSF11 serine/arginine-rich splicing factor 11
SSB Sjogren syndrome antigen B (autoantigen La)
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPR translocated promoter region, nuclear basket protein
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPO1 exportin 1
XPO7 exportin 7
ZBTB1 zinc finger and BTB domain containing 1
ZMYM2 zinc finger, MYM-type 2
ZNHIT6 zinc finger, HIT-type containing 6