BRD-K45399554_CAM-9-027-3_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

439 genes differentially expressed following the BRD-K45399554_CAM-9-027-3_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CALU calumenin
CARS cysteinyl-tRNA synthetase
CCDC92 coiled-coil domain containing 92
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CKAP4 cytoskeleton-associated protein 4
CLCN3 chloride channel, voltage-sensitive 3
CNPY2 canopy FGF signaling regulator 2
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CPM carboxypeptidase M
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CTSL cathepsin L
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHDDS dehydrodolichyl diphosphate synthase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FAM114A1 family with sequence similarity 114, member A1
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FKBP2 FK506 binding protein 2, 13kDa
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GALE UDP-galactose-4-epimerase
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GMPPA GDP-mannose pyrophosphorylase A
GOLGB1 golgin B1
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HBP1 HMG-box transcription factor 1
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGC Ras-related GTP binding C
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
SSR4 signal sequence receptor, delta
STC2 stanniocalcin 2
TACC2 transforming, acidic coiled-coil containing protein 2
TARS threonyl-tRNA synthetase
TM4SF20 transmembrane 4 L six family member 20
TMEM45A transmembrane protein 45A
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN31 tetraspanin 31
TSPYL2 TSPY-like 2
TTC3 tetratricopeptide repeat domain 3
TXNDC15 thioredoxin domain containing 15
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGDH UDP-glucose 6-dehydrogenase
USO1 USO1 vesicle transport factor
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YIPF6 Yip1 domain family, member 6
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CASP8AP2 caspase 8 associated protein 2
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNE1 cyclin E1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO1 enolase 1, (alpha)
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCA Fanconi anemia, complementation group A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GEMIN2 gem (nuclear organelle) associated protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
GZMK granzyme K (granzyme 3; tryptase II)
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP107 nucleoporin 107kDa
NUP210 nucleoporin 210kDa
NUP37 nucleoporin 37kDa
NUP93 nucleoporin 93kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
OXTR oxytocin receptor
P3H2 prolyl 3-hydroxylase 2
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLIRP SRA stem-loop interacting RNA binding protein
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAM transcription factor A, mitochondrial
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2S ubiquitin-conjugating enzyme E2S
UMPS uridine monophosphate synthetase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WDHD1 WD repeat and HMG-box DNA binding protein 1
XPO1 exportin 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein