BRD-K45399554_CAM-9-027-3_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K45399554_CAM-9-027-3_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANXA3 annexin A3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
CAPG capping protein (actin filament), gelsolin-like
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC3 chloride intracellular channel 3
CSTA cystatin A (stefin A)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LITAF lipopolysaccharide-induced TNF factor
LRRC8D leucine rich repeat containing 8 family, member D
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
NREP neuronal regeneration related protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB32 RAB32, member RAS oncogene family
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRPA signal-regulatory protein alpha
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPRED2 sprouty-related, EVH1 domain containing 2
SQLE squalene epoxidase
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TRIB3 tribbles pseudokinase 3
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ANKRD28 ankyrin repeat domain 28
CADM1 cell adhesion molecule 1
CAV2 caveolin 2
CCDC86 coiled-coil domain containing 86
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD59 CD59 molecule, complement regulatory protein
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FOSL1 FOS-like antigen 1
GPM6B glycoprotein M6B
HACD3 3-hydroxyacyl-CoA dehydratase 3
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
LIMS1 LIM and senescent cell antigen-like domains 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NRN1 neuritin 1
NUP107 nucleoporin 107kDa
PI3 peptidase inhibitor 3, skin-derived
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SOX9 SRY (sex determining region Y)-box 9
TGFBI transforming growth factor, beta-induced, 68kDa
TUBB4B tubulin, beta 4B class IVb