BRD-K45399554_CAM-9-027 BRD-K45399554_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K45399554_CAM-9-027 BRD-K45399554_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
ALB albumin
ATM ATM serine/threonine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFB complement factor B
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FZD1 frizzled class receptor 1
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H2BD histone cluster 1, H2bd
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IGF1R insulin-like growth factor 1 receptor
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
NFE2 nuclear factor, erythroid 2
NMRK1 nicotinamide riboside kinase 1
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
ORM1 orosomucoid 1
PCDH7 protocadherin 7
PEG3 paternally expressed 3
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX3 syntaxin 3
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TREM2 triggering receptor expressed on myeloid cells 2
TRIB2 tribbles pseudokinase 2
TRO trophinin
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AK1 adenylate kinase 1
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AREG amphiregulin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATMIN ATM interactor
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CA12 carbonic anhydrase XII
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CHPT1 choline phosphotransferase 1
CNOT7 CCR4-NOT transcription complex, subunit 7
COCH cochlin
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPS8 epidermal growth factor receptor pathway substrate 8
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS2L1 growth arrest-specific 2 like 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HACD2 3-hydroxyacyl-CoA dehydratase 2
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA4L heat shock 70kDa protein 4-like
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KCTD9 potassium channel tetramerization domain containing 9
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
LACTB2 lactamase, beta 2
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
ODC1 ornithine decarboxylase 1
OPN3 opsin 3
PBK PDZ binding kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PRKCZ protein kinase C, zeta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
RPS4Y1 ribosomal protein S4, Y-linked 1
SHCBP1 SHC SH2-domain binding protein 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
STOM stomatin
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UBL3 ubiquitin-like 3
USP1 ubiquitin specific peptidase 1
WDR1 WD repeat domain 1