BRD-K45399554_CAM-9-027 BRD-K45399554_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K45399554_CAM-9-027 BRD-K45399554_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMACR alpha-methylacyl-CoA racemase
ASCL1 achaete-scute family bHLH transcription factor 1
C14ORF1 chromosome 14 open reading frame 1
CD99 CD99 molecule
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAPP E2F-associated phosphoprotein
EPCAM epithelial cell adhesion molecule
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GPX3 glutathione peroxidase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MSMO1 methylsterol monooxygenase 1
MYO10 myosin X
NIPBL Nipped-B homolog (Drosophila)
PCSK1 proprotein convertase subtilisin/kexin type 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
TKT transketolase

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
CA2 carbonic anhydrase II
CD200 CD200 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CELF2 CUGBP, Elav-like family member 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
ISOC1 isochorismatase domain containing 1
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LXN latexin
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTERF3 mitochondrial transcription termination factor 3
MX1 MX dynamin-like GTPase 1
REEP5 receptor accessory protein 5
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
TEX10 testis expressed 10
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPST2 tyrosylprotein sulfotransferase 2