BRD-K45399554_CAM-9-027 BRD-K45399554_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K45399554_CAM-9-027 BRD-K45399554_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEX1 brain expressed, X-linked 1
C14ORF1 chromosome 14 open reading frame 1
CALD1 caldesmon 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALR calreticulin
CAPN1 calpain 1, (mu/I) large subunit
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLC Charcot-Leyden crystal galectin
COL10A1 collagen, type X, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EBP emopamil binding protein (sterol isomerase)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXT1 exostosin glycosyltransferase 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FST follistatin
GM2A GM2 ganglioside activator
HLA-B major histocompatibility complex, class I, B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IPO13 importin 13
IRF6 interferon regulatory factor 6
ITM2C integral membrane protein 2C
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSMO1 methylsterol monooxygenase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG3 paternally expressed 3
PLN phospholamban
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
SST somatostatin
STAR steroidogenic acute regulatory protein
TKT transketolase
TM7SF2 transmembrane 7 superfamily member 2
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOT9 acyl-CoA thioesterase 9
ADGRF5 adhesion G protein-coupled receptor F5
AKAP7 A kinase (PRKA) anchor protein 7
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
ATF1 activating transcription factor 1
C8ORF4 chromosome 8 open reading frame 4
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CENPA centromere protein A
CHSY1 chondroitin sulfate synthase 1
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBNA1BP2 EBNA1 binding protein 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
GALC galactosylceramidase
GOLM1 golgi membrane protein 1
HAT1 histone acetyltransferase 1
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL18 interleukin 18
KIAA0125 KIAA0125
KIF23 kinesin family member 23
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LYPLA1 lysophospholipase I
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PLS3 plastin 3
PPA1 pyrophosphatase (inorganic) 1
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SACS sacsin molecular chaperone
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRGN serglycin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1