BRD-K45044657_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K45044657_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ALB albumin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
C4BPA complement component 4 binding protein, alpha
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COLEC12 collectin sub-family member 12
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
EYA1 EYA transcriptional coactivator and phosphatase 1
EZR ezrin
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HIST1H2BD histone cluster 1, H2bd
HOXC10 homeobox C10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MAP2K6 mitogen-activated protein kinase kinase 6
MGP matrix Gla protein
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
NTS neurotensin
OPN3 opsin 3
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNKP polynucleotide kinase 3'-phosphatase
PON2 paraoxonase 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
RPL38 ribosomal protein L38
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPON1 spondin 1, extracellular matrix protein
STON1 stonin 1
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TSPAN6 tetraspanin 6
TUBB2B tubulin, beta 2B class IIb
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
BICD2 bicaudal D homolog 2 (Drosophila)
CA2 carbonic anhydrase II
CLTB clathrin, light chain B
CXCL13 chemokine (C-X-C motif) ligand 13
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM57A family with sequence similarity 57, member A
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
JADE2 jade family PHD finger 2
LMO4 LIM domain only 4
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPS2 mitochondrial ribosomal protein S2
MT1X metallothionein 1X
NOP16 NOP16 nucleolar protein
PDGFA platelet-derived growth factor alpha polypeptide
PPIF peptidylprolyl isomerase F
PWP1 PWP1 homolog (S. cerevisiae)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZNF593 zinc finger protein 593