BRD-K44849676_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K44849676_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CP ceruloplasmin (ferroxidase)
ECM1 extracellular matrix protein 1
FGF13 fibroblast growth factor 13
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
LCN2 lipocalin 2
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RGS4 regulator of G-protein signaling 4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SDCBP syndecan binding protein (syntenin)
SST somatostatin
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATAD2 ATPase family, AAA domain containing 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
DCN decorin
DEPDC1 DEP domain containing 1
DMD dystrophin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
IFI44L interferon-induced protein 44-like
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
LDHB lactate dehydrogenase B
LPL lipoprotein lipase
MBP myelin basic protein
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NDNF neuron-derived neurotrophic factor
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PDE8B phosphodiesterase 8B
PDZK1 PDZ domain containing 1
PLAC8 placenta-specific 8
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SRPX sushi-repeat containing protein, X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNNC1 troponin C type 1 (slow)
TOP2A topoisomerase (DNA) II alpha 170kDa