BRD-K44432556_VU0418946-2_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

350 genes differentially expressed following the BRD-K44432556_VU0418946-2_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKMY2 ankyrin repeat and MYND domain containing 2
APOLD1 apolipoprotein L domain containing 1
AQP8 aquaporin 8
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BAMBI BMP and activin membrane-bound inhibitor
BCAS1 breast carcinoma amplified sequence 1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAPN6 calpain 6
CARS cysteinyl-tRNA synthetase
CCND1 cyclin D1
CD177 CD177 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSC2 desmocollin 2
DUOX2 dual oxidase 2
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPRS glutamyl-prolyl-tRNA synthetase
ERO1L ERO1-like (S. cerevisiae)
FABP4 fatty acid binding protein 4, adipocyte
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GCLC glutamate-cysteine ligase, catalytic subunit
GLA galactosidase, alpha
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
INHBB inhibin, beta B
ITGB5 integrin, beta 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LITAF lipopolysaccharide-induced TNF factor
LOXL2 lysyl oxidase-like 2
LRP4 low density lipoprotein receptor-related protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NBPF10 neuroblastoma breakpoint family, member 10
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PEA15 phosphoprotein enriched in astrocytes 15
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLCE1 phospholipase C, epsilon 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PTPRR protein tyrosine phosphatase, receptor type, R
QKI QKI, KH domain containing, RNA binding
RAB20 RAB20, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RIOK3 RIO kinase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN4 reticulon 4
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERTAD2 SERTA domain containing 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TBX3 T-box 3
TCF4 transcription factor 4
TF transferrin
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMEM47 transmembrane protein 47
TNIP1 TNFAIP3 interacting protein 1
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VCAN versican
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YAP1 Yes-associated protein 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT1 acetyl-CoA acetyltransferase 1
ACOT7 acyl-CoA thioesterase 7
AHCY adenosylhomocysteinase
ALDOB aldolase B, fructose-bisphosphate
APRT adenine phosphoribosyltransferase
AQP3 aquaporin 3 (Gill blood group)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
AURKA aurora kinase A
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB2 cyclin B2
CD320 CD320 molecule
CD47 CD47 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CTPS1 CTP synthase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBF4 DBF4 zinc finger
DCXR dicarbonyl/L-xylulose reductase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYD dihydropyrimidine dehydrogenase
DUSP2 dual specificity phosphatase 2
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EPHX2 epoxide hydrolase 2, cytoplasmic
F12 coagulation factor XII (Hageman factor)
FAM3C family with sequence similarity 3, member C
FASN fatty acid synthase
FBP1 fructose-1,6-bisphosphatase 1
FGB fibrinogen beta chain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FJX1 four jointed box 1 (Drosophila)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AE histone cluster 1, H2ae
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICMT isoprenylcysteine carboxyl methyltransferase
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MPC2 mitochondrial pyruvate carrier 2
MRPL11 mitochondrial ribosomal protein L11
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPL3 mitochondrial ribosomal protein L3
MRPS12 mitochondrial ribosomal protein S12
MRPS34 mitochondrial ribosomal protein S34
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUTF2 nuclear transport factor 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OXCT1 3-oxoacid CoA transferase 1
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PLA1A phospholipase A1 member A
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRC1 protein regulator of cytokinesis 1
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RAN RAN, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS4 regulator of G-protein signaling 4
RPS21 ribosomal protein S21
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNRPF small nuclear ribonucleoprotein polypeptide F
SRGN serglycin
SRM spermidine synthase
ST7 suppression of tumorigenicity 7
STOML2 stomatin (EPB72)-like 2
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNGR2 synaptogyrin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TDO2 tryptophan 2,3-dioxygenase
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TSTA3 tissue specific transplantation antigen P35B
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2M ubiquitin-conjugating enzyme E2M
UBE2S ubiquitin-conjugating enzyme E2S
UNC13B unc-13 homolog B (C. elegans)
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
ZNF652 zinc finger protein 652
ZWINT ZW10 interacting kinetochore protein