BRD-K44432556_VU0418946-2_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K44432556_VU0418946-2_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BLCAP bladder cancer associated protein
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C4BPA complement component 4 binding protein, alpha
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL9A3 collagen, type IX, alpha 3
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM162A family with sequence similarity 162, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
KDM3A lysine (K)-specific demethylase 3A
KRT23 keratin 23, type I
LEFTY1 left-right determination factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOX lysyl oxidase
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NBPF10 neuroblastoma breakpoint family, member 10
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMYD3 SET and MYND domain containing 3
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BPHL biphenyl hydrolase-like (serine hydrolase)
CCNF cyclin F
CD52 CD52 molecule
CD9 CD9 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHL1 cell adhesion molecule L1-like
CLU clusterin
COCH cochlin
COL3A1 collagen, type III, alpha 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DOCK10 dedicator of cytokinesis 10
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GATA2 GATA binding protein 2
HIST1H2BK histone cluster 1, H2bk
KRT13 keratin 13, type I
LYPD3 LY6/PLAUR domain containing 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
NTS neurotensin
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCL1 phospholipase C-like 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SMC4 structural maintenance of chromosomes 4
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBX2 T-box 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOR1A torsin family 1, member A (torsin A)
TRIB2 tribbles pseudokinase 2
UBE3C ubiquitin protein ligase E3C
WSB2 WD repeat and SOCS box containing 2
WT1 Wilms tumor 1