BRD-K44432556_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K44432556_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGR2 anterior gradient 2
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BLCAP bladder cancer associated protein
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKB creatine kinase, brain
CRLF1 cytokine receptor-like factor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
DUSP5 dual specificity phosphatase 5
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPI glucose-6-phosphate isomerase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
IL6 interleukin 6
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLF1 myeloid leukemia factor 1
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NREP neuronal regeneration related protein
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TF transferrin
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
CCNF cyclin F
CDC25B cell division cycle 25B
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
EFNB2 ephrin-B2
HMGB3 high mobility group box 3
KANK1 KN motif and ankyrin repeat domains 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MMP9 matrix metallopeptidase 9
NRP1 neuropilin 1
PLK1 polo-like kinase 1
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S