BRD-K44432556_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

354 genes differentially expressed following the BRD-K44432556_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALAS2 5'-aminolevulinate synthase 2
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANXA3 annexin A3
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CERS6 ceramide synthase 6
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELL2 elongation factor, RNA polymerase II, 2
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
ERO1L ERO1-like (S. cerevisiae)
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
GPNMB glycoprotein (transmembrane) nmb
GPR87 G protein-coupled receptor 87
GSN gelsolin
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
INSR insulin receptor
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LCN2 lipocalin 2
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PERP PERP, TP53 apoptosis effector
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PKM pyruvate kinase, muscle
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSAT1 phosphoserine aminotransferase 1
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC3 serine incorporator 3
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TF transferrin
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP3 TIMP metallopeptidase inhibitor 3
TMCC1 transmembrane and coiled-coil domain family 1
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YEATS2 YEATS domain containing 2
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZMYM2 zinc finger, MYM-type 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMDHD2 amidohydrolase domain containing 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
COL3A1 collagen, type III, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYC1 cytochrome c-1
DBF4 DBF4 zinc finger
DCTPP1 dCTP pyrophosphatase 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
ECI2 enoyl-CoA delta isomerase 2
ECT2 epithelial cell transforming 2
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EML3 echinoderm microtubule associated protein like 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FAM173A family with sequence similarity 173, member A
FAM64A family with sequence similarity 64, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOXM1 forkhead box M1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPS12 mitochondrial ribosomal protein S12
MRPS34 mitochondrial ribosomal protein S34
MSH6 mutS homolog 6
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NXT1 nuclear transport factor 2-like export factor 1
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALMD palmdelphin
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS23 protease, serine, 23
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TSPAN4 tetraspanin 4
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
ZWINT ZW10 interacting kinetochore protein