BRD-K44432556_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K44432556_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAM28 ADAM metallopeptidase domain 28
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFLAR CASP8 and FADD-like apoptosis regulator
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CSNK1A1 casein kinase 1, alpha 1
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HSPA13 heat shock protein 70kDa family, member 13
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1A interleukin 1, alpha
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PRNP prion protein
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPL37A ribosomal protein L37a
SARS seryl-tRNA synthetase
SERTAD2 SERTA domain containing 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
STC2 stanniocalcin 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2H ubiquitin-conjugating enzyme E2H
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
B3GNT1
BMP4 bone morphogenetic protein 4
C3 complement component 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CSRP1 cysteine and glycine-rich protein 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
HMG20B high mobility group 20B
HMGB3 high mobility group box 3
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
IL32 interleukin 32
KIF20A kinesin family member 20A
LMNB1 lamin B1
MACF1 microtubule-actin crosslinking factor 1
MKI67 marker of proliferation Ki-67
MRPS2 mitochondrial ribosomal protein S2
MVP major vault protein
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RCC1 regulator of chromosome condensation 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TGM2 transglutaminase 2
TRIM14 tripartite motif containing 14
TRIM28 tripartite motif containing 28
UBE2C ubiquitin-conjugating enzyme E2C