BRD-K44432556_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K44432556_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANKRD12 ankyrin repeat domain 12
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CCL20 chemokine (C-C motif) ligand 20
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FEM1C fem-1 homolog c (C. elegans)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GPI glucose-6-phosphate isomerase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INSIG2 insulin induced gene 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
SDC2 syndecan 2
SDC4 syndecan 4
SEC61G Sec61 gamma subunit
SERTAD2 SERTA domain containing 2
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF12 zinc finger protein 12
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ASCL1 achaete-scute family bHLH transcription factor 1
CALR calreticulin
CDC25B cell division cycle 25B
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
COG2 component of oligomeric golgi complex 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ESR1 estrogen receptor 1
FERMT1 fermitin family member 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HSPA1A heat shock 70kDa protein 1A
KANK1 KN motif and ankyrin repeat domains 1
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAMLD1 mastermind-like domain containing 1
MLPH melanophilin
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PDZRN3 PDZ domain containing ring finger 3
PEG3 paternally expressed 3
PRKCA protein kinase C, alpha
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RPIA ribose 5-phosphate isomerase A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOX4 SRY (sex determining region Y)-box 4