BRD-K44432556_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K44432556_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AZIN1 antizyme inhibitor 1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CAPG capping protein (actin filament), gelsolin-like
CAPN1 calpain 1, (mu/I) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COBL cordon-bleu WH2 repeat protein
COL5A1 collagen, type V, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CTSS cathepsin S
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DMXL2 Dmx-like 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EBP emopamil binding protein (sterol isomerase)
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERO1L ERO1-like (S. cerevisiae)
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GP2 glycoprotein 2 (zymogen granule membrane)
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
JAG1 jagged 1
JAM2 junctional adhesion molecule 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LIF leukemia inhibitory factor
LST1 leukocyte specific transcript 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MOXD1 monooxygenase, DBH-like 1
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP2 NLR family, pyrin domain containing 2
NPC1 Niemann-Pick disease, type C1
NREP neuronal regeneration related protein
NRN1 neuritin 1
OLFML2A olfactomedin-like 2A
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI2 peptidyl arginine deiminase, type II
PBX3 pre-B-cell leukemia homeobox 3
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PER3 period circadian clock 3
PGK1 phosphoglycerate kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RUNX1 runt-related transcription factor 1
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STXBP1 syntaxin binding protein 1
TBX3 T-box 3
TGFA transforming growth factor, alpha
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP1 topoisomerase (DNA) I
TPD52 tumor protein D52
TRIM29 tripartite motif containing 29
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACACB acetyl-CoA carboxylase beta
ACSF2 acyl-CoA synthetase family member 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP1 A kinase (PRKA) anchor protein 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA7 annexin A7
ARG1 arginase 1
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLVRA biliverdin reductase A
C1QBP complement component 1, q subcomponent binding protein
CALB2 calbindin 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPM carboxypeptidase M
CRYZ crystallin, zeta (quinone reductase)
CXCL13 chemokine (C-X-C motif) ligand 13
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EML3 echinoderm microtubule associated protein like 3
FASN fatty acid synthase
FMO3 flavin containing monooxygenase 3
G0S2 G0/G1 switch 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS1 growth arrest-specific 1
GCDH glutaryl-CoA dehydrogenase
GHR growth hormone receptor
GRHPR glyoxylate reductase/hydroxypyruvate reductase
HEBP2 heme binding protein 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KDM5D lysine (K)-specific demethylase 5D
KIAA0485 uncharacterized LOC57235
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LYPLA1 lysophospholipase I
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MPC2 mitochondrial pyruvate carrier 2
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL3 mitochondrial ribosomal protein L3
MRPS16 mitochondrial ribosomal protein S16
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MVP major vault protein
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAX5 paired box 5
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDHB pyruvate dehydrogenase (lipoamide) beta
PDHX pyruvate dehydrogenase complex, component X
PEMT phosphatidylethanolamine N-methyltransferase
PLA1A phospholipase A1 member A
PLA2G16 phospholipase A2, group XVI
PNKP polynucleotide kinase 3'-phosphatase
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PRDX2 peroxiredoxin 2
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PVRL3 poliovirus receptor-related 3
RBP4 retinol binding protein 4, plasma
RPA1 replication protein A1, 70kDa
SCP2 sterol carrier protein 2
SCRN1 secernin 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOML2 stomatin (EPB72)-like 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB20 zinc finger and BTB domain containing 20
ZNF544 zinc finger protein 544