BRD-K44276885_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K44276885_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CDCA4 cell division cycle associated 4
COL6A2 collagen, type VI, alpha 2
ESR1 estrogen receptor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAL histidine ammonia-lyase
HBE1 hemoglobin, epsilon 1
HIST1H2BG histone cluster 1, H2bg
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
LAMP1 lysosomal-associated membrane protein 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFE2 nuclear factor, erythroid 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SPRR3 small proline-rich protein 3
STC1 stanniocalcin 1
TCF4 transcription factor 4
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
BIRC5 baculoviral IAP repeat containing 5
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
EPYC epiphycan
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GLS glutaminase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXD1 homeobox D1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI44 interferon-induced protein 44
IRS1 insulin receptor substrate 1
IVNS1ABP influenza virus NS1A binding protein
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
MARCKS myristoylated alanine-rich protein kinase C substrate
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
OSBPL10 oxysterol binding protein-like 10
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RABGGTB Rab geranylgeranyltransferase, beta subunit
REEP5 receptor accessory protein 5
RGCC regulator of cell cycle
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SIX1 SIX homeobox 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb